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KMID : 0603520000050040193
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Journal of Korean Association of Cancer Prevention
2000 Volume.5 No. 4 p.193 ~ p.198
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Chemopreventive Effects of Ferulic Acid and 3-ethyl(4’-geranyloxy-3-methoxyphenyl)-2-propenoate (EGMP) on Colon Carcinogenesis in Rats Treated with Azoxymethane
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Park Cheol-Beom
Kim Dae-Joong
Lee Joon-Sup
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Abstract
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The influence of ferulic acid (FA) and 3-ethyl (4-geranyloxy-3-methoxyphenyl)-2- propenoate (EGMP) on the post-initiation stages of colon carcinogenesis was investigated in male F344 rats treated with azoxymethane (AOM). FA and EGMP were given in the diet at 0.1 or 0.2% starting at week 3 after with two s.c. 15mg/kg body weight injections of AOM on days 1 and 7. Sacrifice for quantitation of aberrant crypt foci (ACF) was performed at the end of week 5. Dose-dependent decreases in numbers of ACF were noted with EGMP cases of post-initiation exposure, large size lesions feeding considered most likely to be precursor lesions also being significantly reduced. In contrast, only feeding 0.2% FA diet had exert inhibiting effect on the incidence of ACF. No effects on body or liver weights were evident. Thus our present results suggest that EGMP may have a potential cancer chemopreventive agent in rat colon carcinogenesis model.
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KEYWORD
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Ferulic acid, 3-Ethyl (4-geranyloxy-3-methoxyphenyl)-2-propenoate (EGMP), Synthetic ferulic acid derivative, Colon carcinogenesis
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